The invention discloses an eddy inhibition and diffusion section drag reduction centrifugal pump asymmetrical water pressing chamber and a centrifugal pump. The eddy inhibition and diffusion section drag reduction centrifugal pump asymmetrical water pressing chamber is internally provided with a runner. The runner comprises a large runner body and a small runner body which extend in the same direction and are arranged side by side. On the water-crossing section perpendicular to the runner, the large runner body communicates with the small runner body, and the area of the large runner body is larger than that of the small runner body. According to the eddy inhibition and diffusion section drag reduction centrifugal pump asymmetrical water pressing chamber, generation and development of eddies in the runner can be guided and restricted, secondary eddies in the water pressing chamber are effectively inhibited, and the eddy intensity in the water pressing chamber is reduced.