The invention discloses a heat exchanger core strapping machine and relates to the core strapping field in the automobile heat exchanger industry. The machine comprises a foundation frame and a main mechanism. The main mechanism is arranged on a guide rail of the foundation frame and connected with a main mechanism leftward-and-rightward movement motor through a screw rod. A distribution box, a touch screen control cabinet, a fixed core supporting plate, an adjustable core supporting plate and a core clamping module are arranged on the foundation frame. A hand wheel is further arranged on the side wall of the foundation frame and connected with the adjustable core supporting plate through the screw rod. The fixed core supporting plate is further arranged at one side of the adjustable core supporting plate. The core clamping module is arranged above the fixed core supporting plate. The heat exchanger core strapping machine is compact in structure, reasonable in design and good in universality; fully-automatic operation is achieved; and it only needs to press down a button twice to strap a core.