The invention discloses large-block compound fertilizer. The large-block compound fertilizer is prepared from components in parts by weight as follows: 80-100 parts of ammonium sulfate, 40-50 parts of ammonium bicarbonate, 30-40 parts of powdered rock phosphate, 20-40 parts of seaweed meal, 30-50 parts of monopotassium phosphate, 20-40 parts of animal fat, 10-30 parts of ammonium molybdate, 1-3 parts of adsorbent resin and 1-2 parts of paraffin coating films. The proportion is simple, the fertilizer efficiency time is long, and fertilizer application is convenient and rapid; specifically, raw materials are put in a heating reaction kettle to be melted and poured into a mold, demolding is performed after cooling, and the spherical fertilizer is formed and has the diameter of 3-5 cm, one fertilizer granule is put in a distance within 30-50 cm during fertilizer application, and the slow release time is greatly prolonged due to the fact that the fertilizer has a large diameter and is condensed and clustered; compared with conventional small-granule fertilizer, the fertilizer has the fertilizer efficiency prolonged by 23%-35%, and the fertilizer application speed is increased by 35%-45%, and accordingly, the fertilizer application cost of a farmer and the production cost of a manufacturer are also greatly reduced.