The invention discloses spandex single jersey and a process for preparing the same. The cylindrical spandex single jersey is free of peripheral seams. A seam cutting working procedure and a presetting working procedure of the traditional process are simplified. The process for manufacturing the cylindrical spandex single jersey particularly includes a weaving technology, a dyeing technology and a finished grey cloth setting technology. Tension on spandex filaments is 1-5 g under the control in weaving working procedures; finished grey cloth is set to form cylinders in finished grey cloth setting working procedures, the drying temperatures are 110-120 DEG C, and over-feeding is 14-18% under the control. The spandex single jersey and the process have the advantages that low-temperature spandex and other low-temperature fiber yarns are mixed with one another and are woven and set by the aid of the cylinder weaving technology; single jersey precedent of seamless shirts is created by seamless fabrics formed by means of cylinder weaving in the aspect of fabrics, and the service field of the spandex single jersey further can be expanded; a seam cutting technology and a presetting technology for low-temperature spandex filament cylinder weaving are omitted from the aspect of technologies, and accordingly the efficiency can be improved.