The invention discloses a method for analyzing reliability of main wiring of a substation by considering line protection, and relates to the reliability analysis of a power system. The method comprises the following steps of firstly, calculating a reliability index of the line protection of the substation and an equivalent reliability index of a circuit breaker controlled by the line protection of the substation; then, utilizing a minimum path set algorithm to calculate the equivalent reliability Rs and the equivalent fault rate lambda[s] of the reliability index of the main wiring of the substation. The method has the advantages that the influence to the reliability of the main wiring of the substation by the line protection is considered, the reliability analysis result of the main wiring of the substation is more scientific, comprehensive and reasonable, and the method is suitable for being applied to actual engineering.