The invention discloses a rotation-type low-voltage isolation switch operation mechanism and belongs to the field of an isolation switch. The operation mechanism comprises a housing and an operation handle arranged on the housing. The front and back sides in the housing are respectively provided with a compression mechanism. The tail end of each compression mechanism is connected with the housing through a rotation shaft. The left and right sides in the housing are respectively provided with a drive mechanism. The drive mechanism is connected with the front end of the corresponding compression mechanism. A bevel gear is arranged between the drive mechanisms. The bevel gear is provided with a stroke cavity. A driving wheel is provided with a groove. The drive mechanisms are connected with the driving wheel through drive blocks. A transmission shaft is connected on the bevel gear. The invention provides the operation mechanism, which is simple in principle, is simple in part structure, is wide in output angle, and is easy to process parts and is easy to adjust parameters in the initial stage of trial-manufacture, to meet requirements of a rotation-type isolation switch, so that quality of the isolation switch is improved, difficulty in the initial stage of trial-manufacture is reduced, and technical personnel are allowed to determine each parameter quickly and accurately.