The invention discloses a visible light MIMO clock synchronization communication system based on an image sensor. The system comprises a display apparatus and the image sensor, wherein the image sensor is connected with a main processing unit, an imaging system is arranged between the display apparatus and the image sensor, each signal of the display apparatus is corresponding to a certain area in an LCD in terms of space, different areas are imaged at corresponding areas on the image sensor through the imaging system, the image sensor converts received optical signals into electric signals, then converts the electric signals into digital signals and transmits the digital signals to the main processing unit, and the main processing unit processes digital images to decode data.