A method of continuous motion digital tomosynthesis includes exposing an object to a programed intensity x-ray beam as an x-ray source travels a pre-determined path, accumulating a signal charge from the x-ray beam, recording the accumulated signal charge into a digital frame image representing raw baseline data, acquiring information on the source's and the detector's position when the recording occurs, compressing the raw baseline data into compressed views, where each respective compressed view is formed by combining the raw data readouts of the respective compressed view, and reconstructing a volumetric breast image by processing each respective compressed view with a reconstruction process function that incorporates the acquired position information and a spatial sampling corresponding to the compressed views. A system configured to implement the method and a computer-readable medium are also disclosed.