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发明公开
CN106459128A 经修饰的胸腺嘧啶多核苷酸寡聚物和方法 有权

经修饰的胸腺嘧啶多核苷酸寡聚物和方法
摘要：
本发明公开了经修饰的胸腺嘧啶碱基，该经修饰的胸腺胸腺嘧啶碱基在多核苷酸杂交复合物中提供对腺嘌呤碱基或2,6-二氨基嘌呤碱基的增强的碱基配对亲合性。还公开了包含此类经修饰的胸腺嘧啶碱基的多核苷酸寡聚物、多核苷酸杂交复合物。还公开了各种使用方法。例如，在一些实施方式中，本文公开的经修饰的多核苷酸寡聚物可用作用于核酸扩增和/或检测的引物和探针。
摘要（英）：

Disclosed are modified thymine bases that provide enhanced base-pairing affinity for adenine or 2,6-diaminopurine bases in polynucleotide hybridization complexes. Also disclosed are polynucleotide oligomers, polynucleotide hybridization complexes that comprise such modified thymine bases. Also disclosed are various methods of use. For example, in some embodiments, modified polynucleotide oligomers disclosed herein can be used as primers and probes for nucleic acid amplification and/or detection.

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