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发明公开
CN106478820A 一种肝癌PET诊断示踪剂及其制备方法与用途 无效 - 撤回

一种肝癌PET诊断示踪剂及其制备方法与用途
摘要：
本发明属于放射性药物及核医学领域，涉及一种肝癌PET诊断示踪剂及其制备方法与用途。本发明的18F标记的抗CD105的羊驼重链单域抗体，结构式为18F-抗CD105的羊驼重链单域抗体。动物实验表明，该18F标记的抗CD105的羊驼重链单域抗体，一方面，肿瘤对其摄取值较高，肿瘤显像灵敏度较高，另一方面，肝脏对其摄取值较低，对肝脏的毒副作用较小；这表明，其可以作为PET诊断示踪剂，特别是作为肝癌PET诊断示踪剂。
摘要（英）：

The invention belongs to the field of radioactive drugs and nuclear medicine, and relates to a liver cancer PET diagnosis tracer agent and a preparation method and application thereof. A 18F marked anti-CD105 alpaca heavy-chain single-domain antibody is shown as a structural formula: 18F-anti-CD105 alpaca heavy-chain single-domain antibody. Animal experiments show that the 18F marked anti-CD105 alpaca heavy-chain single-domain antibody has the advantages that on one hand, uptake values of tumors for the antibody and tumor imaging sensitivity are both high; on the other hand, uptake values of the liver for the antibody is quite low, and accordingly the antibody causes little toxic or side effect on the liver. Thus, the 18F marked anti-CD105 alpaca heavy-chain single-domain antibody can be used as the PET diagnosis tracer agent and the liver cancer PET diagnosis tracer agent in particular.

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