The invention provides a portable skin allergy protection instrument with a voice prompt function. The protection instrument comprises a control module, and a display module, a voice module, an A/D conversion module and a battery module which are electrically connected with the control module. The A/D conversion module is further electrically connected with a dust sensor and a temperature sensor. The voice module is further electrically connected with a speaker and a microphone interface. According to the portable skin allergy protection instrument with a voice prompt function of the invention, data can be displayed on a display in time, the voice prompt function enables patients to read data easily in dim light, and thus, the protection instrument is more user-friendly; the temperature sensor can display the temperature difference between indoor and outdoor in time, so that patients are effectively protected from skin allergy due to too large temperature difference; and a voice chip adopted makes the portable protection instrument adapt to a wider range of people and environments.