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发明公开
CN106492291A 一种含药的医用导管涂层及其合成方法和应用 失效 - 权利终止

一种含药的医用导管涂层及其合成方法和应用
摘要：
本发明属于含药医疗器械领域，具体涉及一种含药的医用导管涂层及其合成方法和应用。该涂层由药物和药物载体组成，所述药物为利福平和盐酸米诺环素，所述药物载体为聚氨酯涂层试剂，所述的利福平与盐酸米诺环素的质量比为1：1～3，所述的聚氨酯涂层试剂，按质量百分含量计，丁酮50%～54%、乳酸乙酯25%～30.6%、四氢呋喃10%～12%、N-甲基吡咯烷酮2.4%～2.8%、聚氨酯聚乙烯吡咯烷酮0.8%～1%、异氰酸基聚氨酯预聚物3%～8%。本发明最大的优点在于：涂层用于医用导管后，导管摩擦系数降低97%，抑菌率达到99%，药物缓释作用达到一个月，具有亲水润滑、抗病菌感染、抗血凝堵塞、药物缓释等功能。
摘要（英）：

The invention belongs to the field of drug-containing medical apparatus and instruments, and particularly relates to a drug-containing medical catheter coating and a synthetic method and application thereof. The coating comprises drugs and a drug carrier, drugs are rifampin and minocycline hydrochloride in the mass ratio of 1:1-3, the drug carrier is a polyurethane coating reagent, and the polyurethane coating reagent comprises, by mass, 50-54% of butanone, 25-30.6% of ethyl lactate, 10-12% of tetrahydrofuran, 2.4-2.8% of N-methyl pyrrolidone, 0.8-1% of polyurethane polyvinylpyrrolidone and 3-8% of isocyanate group polyurethane prepolymer. The coating has the biggest advantages that after the coatign is applied to medical catheters, friction coefficient of the catheters is lowered by 97%, bacteriostasis rate reaches 99%, sustained drug release effect reaches one month, and the coating has functions of hydrophilic lubrication, infection resistance, blood congestion resistance, sustained drug release and the like.

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