The invention discloses a plug-draining device in the tumor hyperthermic perfusion treatment. The device comprises a tank body, wherein a controller is arranged on the right side of the tank body; a separator is arranged at the center of the cavity of the tank body; a heat tank, a booster pump and a flowmeter are arranged on the upper surface of the separator; the heat tank is connected with the inlet of the booster pump through a pipeline, and the outlet of the booster pump is connected with the inlet of the flowmeter through a pipeline; a puncture outfit is arranged at the outlet of the flowmeter; a collection tank and a vacuum extractor are arranged at the bottom of the cavity of the tank body; the collection tank is connected with the inlet of the vacuum extractor through a pipeline. According to the plug-draining device in the tumor hyperthermic perfusion treatment, treatment liquid is heated to a certain temperature by the heat tank and is delivered into the first vacuum extractor through the booster pump, a bent plate in the first vacuum extractor is deformed when impacted, so that pressure fluctuation can be absorbed, and abdominal liquid backflow can be prevented; the puncture head is disposable, the inside of the main pipe is prevented from being polluted, and the device can be used repeatedly, so that certain medical-treatment resource can be saved.