The invention discloses a 3D printed radix notoginseng total saponins orally disintegrating tablet and a preparation method thereof. The preparation method comprises the steps of uniformly mixing, in percentage by weight, 10-30% of radix notoginseng total saponins, 15-35% of microcrystalline cellulose, 30-50% of mannitol, 10-15% of povidone, 0-0.5% of micropowder silica gel and 0-0.5% of a flavoring agent, and putting a mixture into a powder box; putting an adhesive into an ink box; performing modeling according to preset parameters, and importing a model to a control system of a 3D printing and fast-forming machine; outputting an instruction by the control system to print a radix notoginseng total saponins orally disintegrating tablet; and after a dispersible tablet is adhered and dried, taking out the tablet to obtain the 3D printed radix notoginseng total saponins orally disintegrating tablet. According to the 3D printed radix notoginseng total saponins orally disintegrating tablet and the preparation method, the radix notoginseng total saponins orally disintegrating tablet printed by adopting a 3DP technology has the characteristics of simple process, higher disintegrating speed, higher bio-utilization degree, more convenient taking and the like, can be disintegrated in saliva of the oral cavity, and is especially suitable for bedridden patients, apoplectic hemiplegia patients with difficulty in swallowing or old people; and the effect-taking speed is higher, the treatment requirements of acute diseases such as coronary heart diseases, angina and the like are met, and personalized drug administration and accurate treatment can be realized.