The invention provides a vehicle interior ventilation control method and device and belongs to the technical field of vehicles. By means of the vehicle interior ventilation control method and device, the problem that in the prior art, the degree of comfort of the driving environment is not high is solved. The vehicle interior ventilation control method comprises the steps that when a vehicle static ventilation mode is started, a vehicle air conditioner is controlled to enter the external cycle work mode and an air blower of the air conditioner is started when the oxygen concentration and the concentration of carbon dioxide are changed in the first preset time value; and when a high-speed driving ventilation mode is started, according to the detected oxygen concentration, the concentration of carbon dioxide, environment temperatures inside and outside a vehicle as well as the set target temperature, a temperature motor is controlled to work on the promise of ensuring that the oxygen concentration and the concentration of carbon dioxide are maintained at the target concentration values, so that the temperature in the vehicle is maintained at the target temperature. The vehicle interior ventilation control device is used for implementing the vehicle interior ventilation control method. According to the control method and device, the comfort and safety of the environment in the vehicle can be effectively improved when the vehicle is in a running or stop state.