The invention discloses a liquid water-soluble fertilizer high in spreading permeability and high in nutrient content and a preparation method thereof. A spreading permeating agent, namely azone, is added, urea, ammonium nitrate, phosphoric acid, monopotassium phosphate, microelements and the like serve as main raw materials, an anti-crystallization agent serves as a functional auxiliary material, and the liquid water-soluble fertilizer high in spreading permeability and high in nutrient content is prepared through physical and chemical reactions.