A novel diabetes-related immunoloregulation vaccine peptide VP is designed which can effectively prevent T1DM attack and is free of an atherosclerotic side effect. The VP peptide does not cause lipid disorders in serum of mice, sharp hs-CRP level increases or atherosclerosis side effects. The VP peptide can control blood glucose of NOD mice, maintain normal body weights of mice and reduce the incidence of T1DM. In addition, the VP peptide can maintain normal secretion functions of islet beta cells and can allow the cells to exert normal blood sugar adjusting functions.