The invention discloses a cooling and waterproofing power distribution box, which comprises a box body, wherein a fan is arranged in the box body; air outlet through holes connected with the fan and a plurality of air inlet through holes are arranged in the box body; a plurality of trough-type seal plates are also arranged on an outer wall of the box body and cover the air outlet through holes and the air inlet through holes in the box body respectively; the upper ends of the trough-type seal plates are closed and the lower ends of the trough-type seal plates are open; air inlet channels of the air inlet through holes are formed in the side walls of the trough-type seal plates and the box body; a viewing window is formed in the outer wall of the front side of the box body; a head lamp is arranged at the center of the upper side in the box body; the top end of the head lamp is fixed on the inner wall of the upper side of the box body through a connecting rod; and the outer wall of the box body is sequentially provided with a high-temperature resistant layer and an anti-corrosion layer from inside to outside. The cooling and waterproofing power distribution box is good in cooling and waterproofing properties; large-grained impurities can be prevented from entering the box body to affect electronic components; the high temperature resistance and the corrosion resistance are good and the service life is long; furthermore, the internal electronic components can be conveniently observed and maintained; and the cooling and waterproofing power distribution box is easy to operate.