The invention discloses a main-sub-machine heterogeneous in-situ measurement control device applied on an intelligent transformer substation. The device comprises a measurement control main machine and a measurement control sub machine. The measurement control sub machine acquires an actual voltage current simulation amount and a primary equipment position through an AC acquisition end and an input-output acquisition end, and furthermore performs calculation for obtaining an effective value. Furthermore the measurement control sub machine transmits a calculation result to the measurement control main machine through an optical fiber in a private communication protocol manner. The measurement control host machine receives a message and performs analysis. Furthermore the measurement control host machine converts the message to an MMS (industrial automation system manufacturing message specification) message to a station level network. The main-sub-machine heterogeneous in-situ measurement control device applied on the intelligent transformer substation has advantages of realizing in-situ mounting, facilitating secondary loop simplification, saving construction investment, facilitating operation management and improving AC sampling precision.