The present invention relates to a difference Miller band-pass filter and a signal filtering method. The filter comprises an amplifier, a first N-channel feedback network, a second N-channel feedback network and two clock generators; the amplifier performs difference input signals and input matching through the resistance feedback to increase the voltage gain of the input signals for signal amplification, and performs difference output of the signals after filtering; the two clock generators generate periodic sampling pulse sequences and transmit the periodic sampling pulse sequences to the first N-channel feedback network and the second N-channel feedback network; and the first N-channel feedback network and the second N-channel feedback network weaken the signals out of the channels, perform center frequency regulation and conduction operation according to the sampling pulse sequences and perform filtering of the amplified signals. Compared to the prior art, the difference Miller band-pass filter and the signal filtering method can increase the signal gain, increase the 3dB bandwidth of a filter, effectively reduce the chip area and reduce the power consumption of the local oscillator branch.