The embodiment of the invention discloses a method and device for adjusting DNS configuration, and relates to the technical field of communication. The problem of an error in an address inquired by a domain name established by an MME resulting from the change of TAC can be solved. The method disclosed by the embodiment of the invention comprises the following steps: after an analysis request message of a TAI domain name is received, searching whether a history record the same as the TAI domain name exists in business process records generated within a specified time; if the history record the same as the TAI domain name exists, determining whether unsuccessful business process record exists in the history record; if the unsuccessful business process record exists, adjusting the DNS configuration satisfying specified conditions, wherein the DNS configuration satisfying specified conditions at least comprises: DNS configuration with business success rate being smaller than a first threshold and/or a business attempt time greater than a second threshold under the same conditions in the business process record. The method and device disclosed by the embodiment of the invention is suitable for domain name resolution processes.