The invention discloses a multipath interference resisting method. A complete complementary sequence spread-spectrum technology is adopted to design a user baseband signal for transmission. The complete complementary sequence is built through changing the original complementary sequence pair, and even in the case of asynchrony, the orthogonality of the complete complementary sequence can be kept. The perfect orthogonality can resist multipath fading in an MIMO system. The method by adopting the technical scheme of the invention has better performance than the traditional spread spectrum code spread spectrum mode.