The present invention provides a system and a method for processing parameters of a coal-fired unit. The system comprises a front end data acquisition region, a data transmission region and a tail end data storage region. A forward isolation apparatus is connected between the front end data acquisition region and the data transmission region. The front end data acquisition region is used for encapsulating data invoking manners of various data source types and collecting real-time parameters and historical parameters of the coal-fired unit. The data transmission region is used for compressing the collected data and then storing the compressed data in a preset catalog file of a data client. The tail end data storage region is used for writing data of a data service end into a master station database according to a pre-specified file protocol format. Through adoption of the system and method for processing the parameters of the coal-fired unit, the stability, reliability, compatibility and expandability of the data acquisition system are improved effectively.