The invention relates to a deep well saturated salt water base high density heat resistant and anti-pollution drilling fluid which has good basic performance and effectively prevents a well wall from collapsing. According to the technical scheme, the drilling fluid comprises, by mass, 900-1000g of tap water, 30-50g of bentonite for the drilling fluid, 1.5-2.5g of Na2CO3, 3-6g of viscosity and filtration loss reducers SLSP for the drilling fluid, 2-5g of salt-resistant fluid loss agents SCSP for the drilling fluid, 0.5-1.5g of a viscosity reducer PFC for the drilling fluid, 10-20g of an anti-collapse agent HD-2 for the drilling fluid, 5-10g of an anti-collapse agent OSHMK for the drilling fluid and 15-25g of lubricant graphite powder; and finally 40% of alkali liquor is prepared by using NaOH and water, and the pH value of the system is adjusted to 9.0. After stirring for 30 min, according to the mass ratio of barite powder of 0.0530-0.0630 mm to barite powder of 0.0450-0.0530 mm being 3:2, the drilling fluid system is weighted to 2.50 g/cm3, and the deep well saturated salt water base high density heat resistant and anti-pollution drilling fluid is obtained.