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发明授权
CN106552257B 一种基于细胞穿膜肽Tat(49-57)的抗菌肽在抑制细菌方面的应用 失效 - 权利终止

一种基于细胞穿膜肽Tat(49-57)的抗菌肽在抑制细菌方面的应用
摘要：
本发明属于抗菌肽领域，公开一种基于细胞穿膜肽Tat(49‑57)的抗菌肽在抑制细菌方面的应用。该抗菌肽为Tat(YG)、Tat(YY)、Tat(FG)或Tat(FF)，肽链序列依次如SEQ ID No.2‑5所示。这四种衍生抗菌肽对大肠杆菌、鼠伤寒沙门菌、枯草杆菌、金黄色葡萄球菌具有较好的抑制效率，部分菌的抑制率甚至显著高于细胞穿膜肽Tat(49‑57)；并且，这四种衍生抗菌肽的溶血性都很小，在发挥抑菌活性时的浓度均未达到最低溶血浓度。
摘要（英）：

The invention belongs to the field of antibacterial peptide and discloses an application of antibacterial peptide based on cell-penetrating peptide Tat (49-57) in the bacterium restraining aspect. The antibacterial peptide is Tat (YG) or Tat (YY) or Tat (FG) or Tat (FF), and the peptide chain sequences are sequentially shown as SEQ ID No.2, SEQ ID No.3, SEQ ID No.4 and SEQ ID No.5. The four kinds of derived antibacterial peptide have relatively good restraining efficiency for escherichia coli, salmonella typhimurium, bacillus subtilis and staphylococcus aureus, and the restraining efficiency for part of bacteria is even higher than that of the cell-penetrating peptide Tat (49-57); and moreover, the hemolytic rate of the four kinds of derived antibacterial peptide is very small, and the concentration of the four kinds of derived antibacterial peptide does not reach the lowest hemolytic concentration when the four kinds of derived antibacterial peptide achieve the antibacterial activity.

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