The invention relates to an active generator tripping measure configuration method for large power transmission channel fault. The method comprises steps: whether large power transmission channels exist in a power grid system is judged; a fault set in which the power grid system is still out-of-step after caused out-of-step fault is processed by adopting a conventional splitting measure is acquired; a large power transmission channel sub criterion P of the fault c is calculated; a generator tripping number is counted, and a no-fault large power transmission channel power transmission limit sub criterion P is calculated; a power grid system frequency recovery criterion P is calculated; a power set out-of-step sub criterion P of the fault c is calculated; and according to startup delay T and an active generator tripping criterion J corresponding to the fault c, whether to start the active generator tripping measure is judged. The method provided by the invention can effectively handle the out-of-step oscillation problem caused by related large power transmission channel serious fault, the power grid recovery effects are improved obviously, and a perfect configuration scheme is provided for actual operation scheduling of the power grid.