The invention provides a mesh bag opening tying method, a tying component, a bone fusion device, and a using method of the same. The method comprises: a mesh bag is clamped between an inner casing pipe and an outer casing pipe; and a tying device is moved to the opening of the mesh bag, the tying device completes sealing of the mesh bag opening, a bone material implanted and sealed into the mesh bag is exposed through holes of the mesh bag and then is contact with an upper end plate and/or lower end plate. Advantages of rapid tying, simple operation, good adaptation to various intervertebral space, large support area, and high stability are realized.