The invention relates to a water-loss-sensitive thermosensitive time indication device. The water-loss-sensitive thermosensitive time indication device comprises a color changing indication assembly and a dry adsorption assembly. The color changing indication assembly comprises an isolation layer, a substrate layer and an indication layer. The edge of the isolation layer and the edge of the substrate layer are bound together through a first adhesive layer to form a first accommodation body capable of blocking gas; the indication layer is accommodated in the first accommodation body, and is attached to the substrate layer; and the indication layer comprises a water-loss color changing material, wherein the water-loss color changing material is at least one selected from copper sulfate pentahydrate, cobalt chloride hexahydrate, ferric trichloride hexahydrate and copper chloride dehydrate. The dry adsorption assembly comprises a dry adsorption layer accommodated and stored in the second accommodation body in a seal manner, wherein the dry adsorption layer comprises a dry adsorption material capable of absorbing moisture. The water-loss-sensitive thermosensitive time indication device can prevent causing pollution to external environment.