The invention provides toothpaste with an effect of reducing internal heat. Herba verbenae crude extract and herba anoectochili aqueous extract in the toothpaste can be compounded to achieve a synergistic effect; and the toothpaste can effectively kill bacteria, diminish inflammation and relieve pain for harmful bacterial colonies of the oral cavity. Furthermore, the toothpaste has certain effects of reducing the internal heat and relieving the pain and can effectively relieve and treat toothache symptoms through the compound synergistic effect of the components in the toothpaste.