The invention relates to an air purification device good in cleaning effect. The air purification device comprises a body, a filtering mechanism, a sealing mechanism, a spraying mechanism and a sweeping mechanism. The sealing mechanism comprises two sealing assemblies arranged on the upper inner wall and the lower inner wall of the body correspondingly. Each sealing assembly comprises a first motor, two fixed plates, a first drive shaft and a movable plate. The spraying mechanism comprises a water inlet pipe, a first booster pump and an atomization sprayer. The sweeping mechanism comprises a drive assembly and a sweeping assembly. In the air purification device good in cleaning effect, a first filtering assembly and a second filtering assembly are sealed by adding the sealing mechanism, and respective cleaning is convenient to achieve; through the additional arrangement of the spraying mechanism, spraying cleaning is conducted on dirt on a first filtering net; and through the additional arrangement of the sweeping mechanism, the function of sweeping of dirt on a second filtering net is achieved, the function of cleaning the filtering nets in the device can be achieved without opening the device, the detaching frequency is reduced, and the service life of the device is prolonged.