The invention belongs to the technical field of photocatalyst materials and discloses a molybdenum disulfide/MIL-101 composite photocatalyst material, a preparation method thereof and application in the field of antibiotic wastewater degradation treatment, in particular application in the field of degradation of antibiotic wastewater containing ciprofloxacin. The preparation method comprises the following steps: dissolving chromic nitrate, terephthalic acid and hydrofluoric acid into water, uniformly stirring, heating and reacting to obtain MIL-101; dissolving sodium molybdate and thioacetamide into water, uniformly stirring, then adding the MIL-101 obtained in the step (1), uniformly stirring, heating and reacting to obtain the MoS2/MIL-101 composite photocatalyst material. The photocatalyst material disclosed by the invention contains highly dispersed MoS2 nanosheets and more exposed MoS2 active edges, has excellent composite photocatalytic performance and can be applied to antibiotic wastewater degradation treatment, especially realization of efficient degradation treatment on the antibiotic wastewater containing ciprofloxacin.