The invention discloses a mechanical processing cutter box which comprises a box body (1), and a plurality of laminates (2) fixedly mounted in the box body (1) and spaced vertically; a rotating box (3) for containing processing cutters is rotationally mounted at the front part of the upper end of each laminate (2), and rotatable space is reserved between the rotating box (3) and the left end wall, the right end wall and the rear end wall of the box body (1); each rotating box (3) comprises a left cutter groove (31) and a right cutter groove (31) that are bilaterally symmetric, and a sliding groove (33) located between the left cutter groove (31) and the right cutter groove (31); through holes (30) are formed in the centers of the sliding grooves (33) and in the front end parts of the laminates (2); and a left clamping block (91) and a right clamping block (92) are slidingly mounted in one sliding groove (33) in a bilaterally symmetric manner correspondingly.