The invention discloses a 3D printing zirconia based denture material and application of the same and bases on 3D printing ceramic rapid prototyping technology. The denture is evenly mixed in a solvent by zirconia ceramic powder and/or hydroxyapatite bioceramic powder and binder compounded into a molding slurry adapted to an extrusion type 3D printer. The slurry is used to print the ceramic embryo of the personalized denture through the 3D printer. After being sintered at high temperature, the print molded denture ceramic embryo is capable of obtaining a printed zirconia denture with high hardness and good wear resistance. The resulting denture is polished and can be applied to mouths of patients.