The invention discloses a high-energy-density explosive mixture. A low-melting-point single-compound explosive is adopted and comprises, by mass, 5-30% of an adhesive, 15-60% of a main explosive, 15-40% of a combustion agent, 0-25% of an oxidizing agent and 5-50% of a high-density high-energy additive, wherein the adhesive is prepared from trinitrotoluene, 2,4-dimitroanisole and 3,4-dinitrofurazanofuroxan, the main explosive is prepared from RDX, HMX, CL-20, TATB, NTO, NQ, LLM-105 or the mixture thereof, the combustion agent is prepared from aluminum powder, zinc powder, zirconium powder, modified aluminum powder, magnalium powder, boron-aluminum alloy powder, aluminum hydride and magnesium hydride, the oxidizing agent is prepared from ammonium perchlorate, ammonium nitrate and ammonium dinitramide, and thermite is adopted as the high-density high-energy additive. The prepared explosive mixture has the high energy density, the density is larger than or equal to 2.0 g/cm<3>, and the heat of explosion in unit volume is larger than or equal to 16000 J/g.