The invention relates to a rubber sole and provides a slippery resistant safe shoe rubber sole and a preparation method thereof. The provided rubber sole has a strong performance on resisting slipping. The friction coefficient is not less than 0.45 and is obvious higher than the slippery resistant requirements (heelpiece 0.13, smoothness 0.18) of international standard BS EN ISO 20345:2011 personal protective equipment safe shoes. The rubber sole is composed of the following raw materials: high vinyl solution polymerized styrene-butadiene rubber, high acrylonitrile nitrile rubber, NBR/PVC emulsion co-precipitated alloy, white carbon black, an anti-aging agent, polyethylene glycol, a silane coupling agent, polyethylene wax, yellow resin, diglycol, zinc oxide, insoluble sulfur, and a vulcanization promoter.