The invention provides a bootable symbolic execution vulnerability detection method based on path combination. The bootable symbolic execution vulnerability detection method based on path combination comprises the following steps: a, scanning and analyzing a target program to acquire a program control stream related to vulnerability, and marking a path combination range; b, in a symbolic execution process, carrying out abstract collection on the marked range according to information of the acquired program control stream; and c, in the symbolic execution process, directly reusing an abstract when meeting an abstracted program segment to eliminate redundancy exploration, and cutting off program paths unrelated to the vulnerability. The bootable symbolic execution vulnerability detection method has the beneficial effects that the bootable symbolic execution vulnerability detection method based on path combination can eliminate exploration of redundant paths, so that the symbolic execution efficiency and the vulnerability detection precision are improved, and more precise and efficient vulnerability detection is realized.