The invention provides an anti-misopreation method and an anti-misoperation system for one-tower double-circuit zero-sequence pilot protection. The anti-misopreation method comprises the following steps of judging whether a zero-sequence current threshold exists; if yes, establishing a wire breakage fault identification criterion; and determining a zero-sequence direction pilot protection action based on the wire breakage fault identification criterion and fault direction of zero-sequence directional elements at two ends of a line. According to the anti-misoperation method and the anti-misoperation system, through establishing the one-tower double-circuit wire breakage fault identification criterion, a wire breakage fault which may occur in the one-tower double-circuit can be accurately identified, and furthermore a zero-sequence voltage compensation measure for closing complete lines is taken in time.