The invention discloses a comprehensive vulnerability assessment method based on a power communication network structure and state, and the method comprises the following steps: 1, obtaining the impact on the assessment of the vulnerability of the power communication network structure from the vulnerable features of the power communication network structure; 2, obtaining the impact on the assessment of the vulnerability of the power communication network structure from the operation state features of a power communication network; 3, integrating the impact on the assessment of the vulnerability of the power communication network structure from the structural characteristics and operation state features of the power communication network, and obtaining a final power communication network vulnerability assessment result. The method achieve the technical effects that the method can locate a vulnerable link in a network more comprehensively after the integration of the current operation state of the network, and can carry out the vulnerability assessment according to different network topologies and operation states.