The invention discloses a method for determining a pump clearance value of an electric submersible screw pump, and belongs to the field of petroleum and natural gas. The method for determining the pump clearance value comprises the following steps: (1) based on a single-stage bearing pressure of a rotor in the electric submersible screw pump, a coefficient associated with a positive pressure of a stator rubber in the electric submersible screw pump and the single-stage bearing pressure, an elastic coefficient of the stator rubber, and an influence coefficient accumulated value on a single-stage bearing ability, obtaining a work interference amount of the electric submersible screw pump; (2) according to the work interference amount, an interference value generated by the stator rubber via thermal expansion, the interference value generated by the stator rubber via oil expansion, a shrinkage amount generated by the stator rubber under a high pressure condition, and an abrasion amount generated in an operation process of the stator rubber and the rotor, obtaining an initial interference value of the electric submersible screw pump; and (3) based on the work interference amount and the initial interference value of the electric submersible screw pump, obtaining the pump clearance value.