The invention provides a nano carrier with a tumor targeted wrinkled core-shell structure. The nano carrier is prepared by sequentially wrapping outer surfaces of rare-earth upconversion nanoparticles with an upper silicon dioxide layer and a 3-amino isopropyl trimethoxy silane thin layer APTMS from inside to outside, and performing etching treatment on the 3-amino isopropyl trimethoxy silane thin layer. The nano carrier with the tumor targeted wrinkled core-shell structure comprises hyaluronic acid for targeting, the thin layer SiO2/APTMS as a wrinkle layer, and the upconversion nanoparticles as a core. A winkled layer has the advantages of being high in flexibility, large in surface area, short in distance with the upconversion nanoparticles on the core, and the like, light-sensitive molecules can be effectively carried for light power treatment, or fluorescent molecules can be carried for imaging.