The invention relates to external medicinal liquor for treating pain in neck, shoulder, low-back and leg. The external medicinal liquor is prepared by taking radix zanthoxyli, rhizome of Chinese monkshood, radix schefflerae arboricolae and herba lycopi as raw materials, and soaking the raw materials into Baijiu with high alcoholic content. The radix zanthoxyli, the rhizome of Chinese monkshood, the radix schefflerae arboricolae and the herba lycopi are organically combined together and are soaked in the Baijiu with high alcoholic content for extracting effective components; the effects of all the medicines supplement each other; the prepared external medicinal liquor is capable of dredging the blood channel and the sensing channel as well as dissipating blood stasis and relieving pain. The external medicinal liquor is mainly used for treating rheumatic arthralgia and traumatic injury which are caused by qi stagnation and blood stasis, and is mainly used for treating the pain in neck, shoulder, low-back and leg. The external medicinal liquor has the advantages of being easy in material obtaining, simple in preparation, convenient to use, unique in curative effect, and the like; furthermore, the external medicinal liquor is a great contribution to the national medicine and is expected to benefit the public.