The invention discloses a safety device for an interface of a ship and a shore on a wharf. The safety device is suitable for the ship shore connection of various coastal and inland river wharf oil tankers and oil vapor recovery devices or VOCs treating devices in the process of loading and unloading the chemicals. A series of devices, including an insulating flange, a pressure transmitter, a sampling port, an oil gas cutoff system, a filter, a first flame arrester, a pressure/vacuum tapping system, an inert filling/diluting system, a temperature transmitter, an emptying system, a fan, a grounding system and a differential pressure transmitter, are integrated on an integrated sledding chassis. Instrument signals and interlocking relations in the devices are integrated in a PLC control system, so that safe and stable running of the oil vapor recovery system is guaranteed when the ship is subjected to the operation of loading and unloading the oils and chemicals. The safety device is suitable for the occasions of oil vapor recovery and VOCs treatment for loading and unloading the oils and chemicals of the coastal and inland river ships.