The invention discloses health care wine taking insects as main materials. The health care wine comprises, by weight, 5-10 parts of brachytrupes portentosus lichtenstein, 1-3 parts of cordyceps cicadae, 3-5 parts of silverfish, 6-10 parts of mole crickets, 5-7 parts of dung beetles, 1-4 parts of big dragonflies, 6-12 parts of black ants, 6-8 parts of neostylopyga rhombifolia and 100-500 parts of baijiu. Eight insects are dipped and prepared into the health care wine, the health care wine has the functions of relieving toxin, dredging stranguria, inducing diuresis and relaxing the bowels, can serve as daily drinking health care wine and has health care effects of tonifying kidney, benefiting liver, invigorating bones, resisting fatigue, enhancing immunity and the like.