The invention discloses a high pressure-bearing blocking method for a perforation shot hole. A leak source is determined firstly, two whole sealing bridge plugs are plugged into the lower portion of the leak source, clear water pressure testing is conducted, the pressure for opening a stratum is determined, and then blocking is conducted. Gelatin spacer fluid and leaking stoppage glue are pumped into a continuous oil pipe to enable the leaking stoppage glue to enter a to-be-blocked perforation shot hole, and the continuous oil pipe is uplifted. Clear water is injected into the continuous pipe through extruding, and pressure keeping down and cement setting waiting are conducted. Finally pressure relief is conducted, and the continuous oil pipe is pulled out. According to the high pressure-bearing blocking method for the perforation shot hole, the blocking effect is good, the perforation shot hole with a large aperture can be blocked, the pressure-bearing capacity reaches 70 MPa or more, and the requirement for subsequent fracturing operation can be met.