The invention discloses a pneumatic fluorine-lined corrugated pipe single seat adjusting valve and relates to the technical field of manufacturing of a special valve. The pneumatic fluorine-lined corrugated pipe single seat adjusting valve comprises a valve body, a valve core, a valve rod and a valve core. A mounting connecting port is further mounted in the valve body, a middle flange is arranged on the mounting connecting port, a sealing end surface matched with the valve core is arranged in a middle section of a water channel between the inlet and the outlet of the valve body, the valve core is fixed at one end of the valve rod, the valve core is arranged in the valve body, the mounting connecting port is connected to the valve cover through the middle flange, and a packing sealing mechanism is arranged between the valve core and the valve rod; a polytetrafluoroethylene corrugated pipe is arranged on the valve rod in the valve body, two ends of the polytetrafluoroethylene corrugated pipe separately lean against the inner end surface of the valve core and the end surface of the valve core, a pneumatic executor is fixedly connected to the upper end of the valve body through a bracket, and the output end of the pneumatic executor is fixedly connected to the top end of the valve rod. By using the polytetrafluoroethylene corrugated pipe as a first seal, a medium is effectively prevented from being leaked from the valve rod, so that zero leakage is formed; the valve is controlled to open and close by the pneumatic executor, so that the pneumatic fluorine-lined corrugated pipe single seat adjusting valve is accurate in stroke and safe and reliable.