The invention belongs to the field of spacecraft assembly structure design and particularly relates to a pipeline cabin penetration flange of a spacecraft sealed cabin body. The high-heat-resistance sealed cabin pipeline cabin penetration flange comprises a cup-shaped flange base, a guide pipe and a supporting gasket. The cup-shaped flange base comprises a cup body and a flange base body. One end of the guide pipe penetrates through the cup bottom of the cup body in the cup-shaped flange base and is fixed through welding, and the other end of the guide pipe penetrates through a central through hole of the flange base body. A gap between the other end of the guide pipe and the central through hole of the flange base body is filled through the supporting gasket. Ventilation holes are circumferentially and uniformly distributed in the supporting gasket. The cup-shaped flange base of the pipeline cabin penetration flange has the characteristic of high heat resistance and adopts the towering cup body type design, the path where heat of a spacecraft cabin body structure is transmitted to the guide pipe can be prolonged, and the transmission efficacy of the heat is effectively relieved.