The invention discloses an MOEMS wireless vibration sensor based on a comb grid and an operation method thereof. The MOEMS wireless vibration sensor comprises a sensor housing. A miniature light source is connected with a vibration sensitive source through a transmission optical fiber. Collimators are fixed at two sides of the vibration sensitive source. The output end of the vibration sensitive source is connected with a photoelectric conversion module through the transmission optical fiber. The photoelectric conversion module is successively connected with a data analysis module and a wireless transmission module. The MOEMS wireless vibration sensor has a beneficial effect of requiring effective contact between the sensor and a measured object in monitoring, and furthermore a wireless transmission function of a detecting signal effectively overcomes a defect of high difficulty in sensor arrangement and wiring in large-size engineering structure monitoring such as channel and bridge.