The invention discloses a laser tracking measurement apparatus multi-target measuring method and apparatus based on inertia guiding. The invention integrates an inertia measurement apparatus and a laser tracking measurement apparatus to form a combined measurement system, and provides a laser tracking measurement apparatus multi-target automatic measuring method based on inertia guiding. The inertia measurement apparatus autonomously works in a high frequency and is not influenced by on-site environment, and continuously provides guiding information for the laser tracking measurement apparatus in real time; and meanwhile, the laser tracking measurement apparatus outputs the accurate and stable measurement result to correct the accumulative error of the inertia measurement apparatus. The advantages of the two measurement methods and apparatuses are combined, the disadvantages of each other can be made up, and a measuring apparatus with optimal comprehensive performance can be formed.