The invention discloses a die-casting mould pouring parameterization design system and method. The system comprises a gate design module, a runner design module, a 3D sprue design module, an overflow system design module and an analysis and modification design module; the gate design module comprises a fan gate design unit, a cutting gate design unit and an inner gate design unit; the runner design module comprises a branch runner design unit, a step runner design unit, a spreader design unit, a sinter cake design unit and a runner connection design unit; the 3D sprue design module comprises a 3D fan gate design unit, a 3D runner design unit, a 3D cutting gate design unit and a 3D inner gate design unit; the overflow system design module comprises a slag ladle design unit and an exhaust design unit; the analysis and modification design module comprises a cross section change analysis design unit and a feature variable parameter modification design unit. Through the die-casting mould pouring parameterization design system and method, the design process of a pouring system is well normalized, the design time of the pouring system is shortened, and design efficiency and quality are improved.