The invention discloses an optimum efficiency tracking based self-adaptive wireless power supply system. The optimum efficiency tracking based self-adaptive wireless power supply system includes a transmitting terminal and a receiving terminal. The transmitting terminal includes a first control module, and a BUCK-BOOST module, a first voltage current detecting module, a first Bluetooth module and a first LC parallel resonance module connected with the first control module separately. The BUCK-BOOST module is connected with the first voltage current detecting module. The first voltage current detecting module is connected with the first LC parallel resonance module. The receiving terminal includes a second control module, and a second LC parallel resonance module, a rectifier module, a voltage stabilizing module, a second voltage current detecting module and a second Bluetooth module connected with the second control module separately. The second LC parallel resonance module is connected with the rectifier module. The rectifier module is connected with the voltage stabilizing module. The voltage stabilizing module is connected with the second voltage current detecting module. By adopting the optimum efficiency tracking based self-adaptive wireless power supply system, optimum efficiency tracking can be realized and the optimum efficiency in current charging state can be found.